Heidari et al ( 20) reported a protective effect of Such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and Supplementation may substantially reduce inflammatory cytokines, Secretion of cytokines and activation of glial cells. Well-known critical event in TBI, which may be mediated by the Lotocki et al ( 18) reported that inflammation is a Ischemia, oxidative stress, apoptosis, inflammation,Įxcitotoxicity, and vascular and neuronal damage may also cause TBI The most common cause of TBI isĮxternal force to the brain, and it can be classified as closed or Traumatic brain injury (TBI) leads to cognitiveĭeficits, high mortality, and impaired movement ( 14). Recovery, and prevention of seizures ( 7– 13). Homeostasis, obesity prevention, excitotoxicity, osmotic shock Neurotransmission, detoxification, osmoregulation, calcium Of lipids and apolipoprotein B100 in liver cancer cells ( 6). Taurine is an effective antioxidant against lead-,Ĭadmium-, and exercise-induced oxidative stress ( 5), and is known to reduce the secretion Role in regeneration and neuroprotection in the injured nervous Rak et al ( 4) demonstrated that taurine plays a key Taurine in the central nervous system, as well as its functions inĬardiovascular and skeletal muscle. Huxtable ( 3) have reported on the functional role of To play a critical nutritional role in brain cell growth,ĭifferentiation, and development ( 2). Taurine is a non-proteogenic and essential amino Thus, taurine supplementation may be effective against oxidative stress, apoptosis, and inflammation in injured brain cells. These inflammatory, apoptotic, and oxidative stress markers were substantially increased in injured cells, and returned to normal levels following taurine supplementation. Astrocytes and neuron cells were co‑cultured and cells were treated with different concentrations of taurine (100, 200 and 300 mg/l) for 72 h, and the levels of reactive oxygen species, malondialdehyde, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase, acetylcholinesterase, tumor necrosis factor‑α, interleukin‑6, caspase‑3, p53, B‑cell lymphoma 2 and Bcl‑2‑associated X protein were determined. Taurine is involved in regeneration and neuroprotection in the injured nervous system, and is an effective antioxidant against lead‑, cadmium‑, and exercise‑induced oxidative stress. It plays a critical nutritional role in brain cell growth, differentiation, and development.

Taurine is a non‑proteogenic and essential amino acid in animals. The protective effect of taurine against inflammation, apoptosis and oxidative stress in traumatic brain injury was investigated in the present study.

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